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Cockcroft-Gault Creatinine Clearance

Estimation of creatinine clearance (CrCl) for drug dose adjustment.

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Sex
Score72.9low risk
low riskmoderate riskhigh risk

Mild renal impairment (60–89 mL/min). Monitor kidney function and check package inserts for narrow therapeutic index drugs.

Evidence grade
A

Formulas and cut-offs are from the original authors of each score; see the references.

Last reviewed: June 2026

References
  1. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. PMID:1244564